Endocrine Abstracts

Celastrol, a triterpene compound derived from the thunder god vine (Tripterygium wilfordii), has shown promising efficacy in preclinical models for the management of metabolic disorders such as obesity and diabetes. The compound exhibits anti-inflammatory properties and has been shown to enhance insulin sensitivity and modulate lipid metabolism. The observed weight loss effects are thought to be primarily mediated by its ability to augment leptin sensitivity. Despite extensive...

Background: A normal islet includes both mature and immature β-cells, with the former possessing higher insulin content and the latter displaying better proliferative capacity. However, it remains unknown whether immature β-cells also contribute to the regulation of insulin release, especially by commanding the activity of their mature counterparts.Materials and methods: Pdx1, Mafa, and Ngn3 were overexpressed in &#94...